In vitro results suggest that Physeptone undergoes hepatic N-demethylation by cytochrome P450 enzymes, principally CYP3A4, CYP2B6, CYP2C19 and to a lesser extent by CYP2C9 and CYP2D6. Coadministration of Physeptone with CYP inducers of these enzymes may result in a more rapid metabolism and potential for decreased effects of Physeptone, whereas administration with CYP inhibitors may reduce metabolism and potentiate methadones effects. Although antiretroviral drugs such as efavirenz, nelfinavir, nevirapine, ritonavir, lopinavir+ritonavir combination are known to inhibit CYPs, they are shown to reduce the plasma levels of Physeptone, possibly due to their CYP induction activity. Therefore, drugs administered concomitantly with Physeptone should be evaluated for interaction potential; clinicians are advised to evaluate individual response to drug therapy.


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What it is used for

PHYSEPTONE is indicated for the management of severe pain where: (i) other treatment options have failed, are contraindicated, not tolerated or are otherwise inappropriate to provide sufficient management of pain, and (ii) the pain is opioid-responsive, and (iii) requires daily, continuous, long-term treatment. ,PHYSEPTONE is not indicated for use in chronic non-cancer pain other than in exceptional circumstances.,PHYSEPTONE is not indicated as an as-needed (PRN) analgesia.,PHYSEPTONE is not recommended for use in ambulant patients.

How to take it

The way to take this medicine is: Oral. This medicine is taken by mouth.

  • Store below 25 degrees Celsius
  • Protect from Light
  • Store in a Dry Place
  • Shelf lifetime is 24 Months.

You should seek medical advice in relation to medicines and use only as directed by a healthcare professional.

Always read the label. If symptoms persist see your healthcare professional.

Visual appearance

White biconvex scored tablet on one side and plain on the other

Images are the copyright of the Pharmacy Guild of Australia

Do I need a prescription?

This medicine requires authorisation for prescription from your doctor. It is Schedule 8 : Controlled Drug.

Is this medicine subsidised?

This medicine was verified as being available on the PBS (Pharmaceutical Benefits Scheme) on May 1, 2021. To learn more about this subsidy, visit the Pharmaceutical Benefits Scheme (PBS) website.

Pregnant or planning a pregnancy?

For the active ingredient methadone

You should seek advice from your doctor or pharmacist about taking this medicine. They can help you balance the risks and the benefits of this medicine during pregnancy.

Download leaflet

For side effects, taking other medicines and more

Download consumer medicine information leaflet (pdf) from the Therapeutic Goods Administration (TGA) website

Reporting side effects

You can help ensure medicines are safe by reporting the side effects you experience.

You can report side effects to your doctor, or directly at

Additional information


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